Access to Compounds

Information about selected novel compounds discovered or used in the Conn Lab

Our goal is to make all published compounds developed in our labs available to the scientific community. While our limited capacity for synthesis prevents us from supplying our compounds on a broad basis, we are pleased that some compounds have been made available through commercial vendors. In addition, we provide detailed synthetic protocols for novel compounds to facilitate their synthesis by other laboratories. Below is a partial list of commercially available compounds and their sources followed by links to synthetic protocols of other compounds that we have reported. The following is provided for informational purposes only.

mGluR1 Positive Allosteric Modulators
Ro 67-4853 (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester Tocris Bioscience Cat. no. 4347

mGluR4 Positive Allosteric Modulators
PHCCC (E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide Abcam Biochemicals Cat. no. Asc-043 Tocris Bioscience Cat. no. 1027

VU0155041 cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid Abcam Biochemicals Cat. no. Asc-244 - VU0155041 Cat. no. Asc-248 - VU0155041 sodium salt Biotrend Chemicals Cat. no. BN0755 - VU0155041 Cat. no. BN0756 - VU0155041 sodium salt Sigma-Aldrich Cat. no. V1640 Santa Cruz Biotechnology Cat. no. sc-204386 - VU0155041 sodium salt Tocris Bioscience Cat. no. 3248

VU0361737 N-(4-chloro-3-methoxyphenyl)picolinamide Tocris Bioscience Cat. no. 3707

mGluR5 Positive Allosteric Modulators
CDPPB 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide EMD Biosciences Cat. no. 445865 Tocris Bioscience Cat. no. 3235 Abcam Biochemicals Cat. no. Asc-363

CPPHA N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide Axon Medchem Cat. no. Axon 1431

DCB 3,3'-Dichlorobenzaldazine or (1E,2E)-1,2-bis(3-chlorobenzylidene)hydrazine Santa Cruz Biotechnology Cat. no. sc-203560 Tocris Bioscience Cat. no. 1952

DFB 3,3'-Difluorobenzaldazine or (1E,2E)-1,2-bis(3-fluoroenzylidene)hydrazine Santa Cruz Biotechnology Cat. no. sc-203918 Tocris Bioscience Cat. no. 1625

VU1545 N-[1-(2-Fluorophenyl)-3-phenyl-1H-pyrazol-5-yl]-4-nitrobenzamide Santa Cruz Biotechnology Cat. no. sc-204388 Tocris Bioscience Cat. no. 3325

VU29 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Axon Medchem Cat. no. 1425

M1 mAchR Allosteric Agonist
VU0357017 Ethyl 4-({2-[(2-methylphenyl)formamido]ethyl}amino)piperidine-1-carboxylate hydrochloride Sigma-Aldrich Cat. no. V4640

M1 mAchR Antagonist
VU0255035 N-(3-oxo-3-(4-(pyridine-4-yl)piperazin-1-yl)propyl) benzo[c][1,2,5]thiadiazole-4-sulfonamide hydrate CAS # 1135243-19-4 Santa Cruz Biotechnology Cat. no. sc-258334 Sigma-Aldrich Cat. no. V3765 Tocris Bioscience Cat. no. 3727

M1 mAchR Positive Allosteric Modulators
BQCA 1-[(4-methoxyphenyl)methyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Biotrend Chemicals Cat. no. BN0815 Enzo Life Sciences Cat. no. BML-C121-0010 and BML-C121-0050

M4 mAchR Positive Allosteric Modulators
VU10010 3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Tocris Bioscience Cat. no. 3141

VU152100 3-amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide Axon Medchem Cat. no. Axon 1483 Tocris Bioscience Cat. no. 3383

M5 mAchR Positive Allosteric Modulators
VU0238429 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione Tocris Bioscience Cat. no. 3634