Gregory J. Digby, Ph.D.

Research Fellow

     B.S.    Biology, Georgia Southern University, 2000
     M.S.    Biology, Georgia Southern University, 2003
     Ph.D.  Neuroscience, Medical College of Georgia, 2008

Biosketch and Research Interests
Gregory J. Digby, Ph.D., is a post-doctoral researcher that joined the Conn laboratory in September 2008. Prior to joining, he obtained his doctorate at the Medical College of Georgia. Greg trained in the laboratory of Nevin A. Lambert, Ph.D. where his work focused on measuring G protein dynamics in living cells. Using Fluorescence Recovery After Photobleaching (FRAP) and Fluorescence Energy Transfer (FRET) microscopy he showed that active G protein heterotrimers are in continuous dissociation/reassociation equilibrium. In the Conn lab he focuses on determining differential signal transduction downstream of M1 muscarinic receptors.

Selected Publications

Willard F.S., Zheng Z., Guo J., Digby G.J., Kimple A.J., Johnston C.A., Bosch D., Willard M.D., Lambert N.A., Ikeda S.R., Du Q., and Siderovski D.P. A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding: Direct Evidence For Gα/GoLoco Complexes in Mitotic Spindle Dynamics, Journal of Biological Chemistry, (Submitted).

Digby G.J., Sethi, P.R., Lambert, N.A., Differential dissociation of G protein heterotrimers in living cells, Journal of Physiology, 2008, 586: 3325-3335.

Digby G.J., Lober, R.M., Sethi, P.R., Lambert, N.A., Some G-protein heterotrimers physically dissociate in living cells, Proceedings of the National Academy of Sciences, 2006, 103: 17789-17794.