Tristano Pancani, Ph.D.
B.S. Biology, University of Florence, 2003
Ph.D. Pharmacology, University of Kentucky, 2010
Biosketch and Research Interests
Tristano Pancani joined the Conn Lab in October 2011 as a postdoctoral fellow. He received his Ph.D. at University of Kentucky in the lab of Dr. Thibault. At UK his work focused on the study of the effects of the thiazolidinediones (TZDs, a family of antidiabetic drugs) on neuronal Calcium homeostasis and glucose metabolism. Using a combination of electrophysiology and calcium/glucose imaging, his research unveiled novel mechanism of action and targets of TZDs in the brain. In the Conn laboratory Tristano's research focuses on determining the roles of M1 and M4 muscarinic receptors in striatal network function.
Pancani T, Anderson KL, Porter NM, Thibault. 2011. Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: Dynamic responses to depolarization and sensitivity to pioglitazone. O. Cell Calcium.
Blalock EM, Phelps JT, Pancani T, Searcy JL, Anderson KL, Gant JC, Popovic J, Avdiushko MG, Cohen DA, Chen KC, Porter NM, Thibault O. 2010. Effects of long-term pioglitazone treatment on peripheral and central markers of aging. PLoS One.5(4):e10405.
Pancani T, Phelps JT, Searcy JL, Kilgore MW, Chen KC, Porter NM, Thibault O. 2009. Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. J Neurochem. 109(6):1800-11.
Werner CG, Scartabelli T, Pancani T, Landucci E, Moroni F, Pellegrini-Giampietro DE. 2007. Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of ischemic tolerance. Eur J Neurosci. 25(12):3597-604.
Faraco G, Pancani T, Formentini L, Mascagni P, Fossati G, Leoni F, Moroni F, Chiarugi A. 2006. Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain. Mol Pharmacol. 70(6):1876-84.
Adembri C, Venturi L, Tani A, Chiarugi A, Gramigni E, Cozzi A, Pancani T, De Gaudio RA, Pellegrini-Giampietro DE. 2006. Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. Anesthesiology. 104(1):80-9.