Huiyong Yin, Ph.D., is a Research Assistant Professor in the Departments of Medicine and Chemistry who joined the Vanderbilt Program of Drug Discovery in Feb., 2007. He is leading the efforts on the study of  in vitro and in vivo drug metabolism and pharmacokinetics (DMPK). Huiyong obtained his doctoral training in the Department of Chemistry at Vanderbilt University in the laboratory of Dr. Ned Porter. His graduate work was focused on organic peroxides and free radical chemistry. He was also interested in free radical oxidation products of polyunsaturated fatty acids and identification of these oxidation products using liquid chromatography and mass spectrometry. He joined Dr. Jason Morrow’s laboratory in the Division of Clinical Pharmacology in 2002 and worked on biological significance of lipid oxidation products such as isoprostanes and their role in human diseases. Huiyong is the winner of Young Investigator Award and Travel Award from Society of Free Radical in Biology and Medicine (SFRBM), Warren Graduate Fellowship Award from Chemistry Department at Vanderbilt University, and President’s Graduate Award of the Chinese Academy of Sciences. He has published over 50 papers in peer-reviewed journals.

Selected Publications:

• Porter NA, Yin H, Pratt DA. The Peroxy Acid Dioxirane Equilibrium: Base-Promoted Exchange of Peroxy Acid Oxygens. J. Am. Chem. Soc. 122:11272-23, 2000.
• Yin H, Havrilla CM, Morrow JD, Porter NA. Formation of Isoprostane Bicyclic Endoperoxides from the Autoxidation of Cholesteryl Arachidonate. J. Am. Chem. Soc., 124:7745-54, 2002.
• Yin H, Havrilla CM, Gao L, Morrow JD, Porter NA. Mechanisms for the Formation of Isoprostane Endoperoxides from Arachidonic Acid: "Dioxetane" Intermediate or b-Fragmentation of Peroxyl Radicals? J. Biol. Chem., 278:16720-25, 2003.
• Masterson DS, Yin H, Chacon A, Hachey DL, Norris JL, Porter NA. Lysine Peroxycarbamates: Free Radical-Promoted Peptide Cleavage. J. Am. Chem. Soc., 126:720-21, 2004.
• Yin H, Morrow JD, Porter NA. Identification of a Novel Class of Endoperoxides from Arachidonate Autoxidation. J. Biol. Chem., 279:3766-76, 2004.
• Musiek ES, Yin H, Milne GL, Morrow JD. Recent Advances in the Biochemistry and Clinical Relevance of the Isoprostane Pathway”. Lipids, 40(10), 987-94, 2005.
• Yin, H., Gao, L., Tai, H.-H., Murphey, L. J., Porter, N. A., and Morrow, J. D. Urinary Prostaglandin F2a Is Generated from the Isoprostane Pathway and Not the Cyclooxygenase in Humans. J. Biol. Chem. 282, 329-336, 2007.
•  Gao, L., Yin, H., Milne, G. L., Porter, N. A., and Morrow, J. D. Formation of F-ring Isoprostane-like Compounds (F3-Isoprostanes) in Vivo from Eicosapentaenoic Acid. J. Biol. Chem. 281, 14092-14099, 2007.